Chronic fatigue syndrome objective diagnostic method has yet been established. Therefore, currently, various tests have similar symptoms to other diseases could be excluded and, as been diagnosed. Mie University research team for 10 days, chronic fatigue syndrome patients in the blood, characteristic of extracellular vesicles is increased, and extracellular small body of about the ingredients, the actin network proteins that make up high number of was found and announced.
Future, this protein bio-markers for Chronic Fatigue Syndrome objective diagnose, and protein release mechanism study,disease the onset of this research is expected to lead to.
In this study, the Mie University of Eguchi, Akiko lecturer, Kansai welfare science at the University of Fukuda, Sanae Professor,倉恒 弘彦 Professor,RIKEN RIKEN Center for Life Science Technologies team leader at the University of California, San Diego School of Ariel E. Feldstein, Professor of participation.
Myalgic encephalomyelitis/chronic fatigue syndrome[ME/CFS:Myalgic encephalomyelitis/Chronic Fatigue Syndrome]is life, there is trouble in the most heavy fatigue of 6 months or longer disease. The cause is identified and treatment has not been established.
Diagnosis,similar symptoms that can cause renal failure and rheumatism, thyroid abnormalities, such as the possibility of exclusion as a result performed. Therefore a definitive diagnosis is difficult, and the ME/CFS-specific biomarker discovery is desired.
Research group, first ME/CFS patients and healthy controls in blood by comparison, the flow cytometry method in cell surface antigen expression was investigated. Also included proteins that comprehensively examine the source system analysis was performed.
As a result, ME/CFS patients in the blood by extracellular vesicle contains a lot of found that. Extracellular vesicles and all of the cells emitted from extremely small particles, in that it is protein or nucleic acid is included, and cellular communication used to that.
In addition, this extracellular vesicle components analysis. When ME/CFS patients,The Shape of the cell to maintain a important,fillers and Tallinn, including the actin network configuration contains a lot of protein found. This is within six months of fatigue accompanied by symptoms[subacute fatigue] patients, and depressed patients as compared to higher number was.
As a result, the blood levels of extracellular vesicle-actin network proteins, the ME/CFS diagnostic biomarker could be suggested. This new biomarker, this was a difficult task in depressed patients and subacute fatigue patients with an objective diagnosis of the determination can be considered.
The future of the actin network protein extrusion mechanism obviously, the ME/CFS pathogenetic mechanisms,further treatments lead to the development of as can be expected.
The research team in the future,this protein is a different race, even as biomarkers useful to consider what plans,General Medical Institutions available to such commercialization also decided that it will move ahead.
The results of research,11 month 26 days of Brain, Behavior and Immunity Online, published. [Article: 室園 美映子・The article list to look at]