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Diabetes is "functionally cured" with a new method of stem cell therapy. Normalized blood glucose for 9 months in mouse experiments-Engadget Japan

Washington University School of Medicine

Dr. Jeffrey R. Millman, a researcher at the University of Washington School of Medicine, turned human stem cells into insulin-producing cells and administered them to severely diabetic mice. The research results that diabetes could be cured were announced.

Millman discovered a few years ago how to convert human stem cells into pancreatic beta cells, and they knew that beta cells would begin to secrete insulin when exposed to high blood sugar levels, but at the time they could improve blood sugar levels. I didn't get to the point where I could control it. According to a study published in Nature Biotechnology, a recent study showed that insulin-secreting cells were administered to mice that had a blood glucose level of 500 mg per deciliter (lethal for humans), Has improved, and has maintained normal condition for 9 months.

Normally, when converting stem cells to a specific type of cell, some random factors occur, and some types of cells that are not of interest are mixed. While these cells do not hurt, they generally reduce the strength of their intended role relative to the amount of cells produced.

For example, if you need about 1 billion beta cells to treat a diabetic patient, and if one-quarter of the cells you make from stem cells are hepatocytes and other pancreatic cells, you need to make them. One billion is not enough, and at least 1.25 billion is needed to account for the reduced functionality.

For this reason, Millman said he was studying a new method that focused on reducing the percentage of wasted cells so that a higher percentage of beta cells could be generated and functioning. "This is a completely different approach. We used to identify a variety of proteins and factors and see how they could make changes to cells, but now the changes that occur I was able to better understand the signal and reduce the proportion of cells that are being wasted, "says Millman.

The new method works efficiently with stem cells from multiple different sources, greatly enhancing its ability to study disease.

With all this good news, we hope that the general public and patients with actual diabetes will soon be able to apply it to human treatment, but Millman still has to do this before bringing it to clinical trials. Explain that there are many things. Because good results in mice are not enough to show a similar effect in humans, the team has done longer trials on larger animals and hoped that one day they could save a lot of diabetics. I will continue my research.

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