It is confirmed in monkey experiments that antibodies that protect the body from novel coronavirus are produced by vaccine
Conducted by a research team at Harvard Medical School,Rhesus monkeyTo prototypeDNA vaccineAnd an experiment inoculating the new coronavirus (SARS-CoV-2) confirmed that the vaccine protects rhesus monkeys from SARS-CoV-2. It is reported that the expectation that this will lead to the development of a new type of coronavirus infectious disease (COVID-19) vaccine for humans is increasing.
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Dan H. Barouch, a professor of medicine at the Harvard Medical School and director of the Virology and Vaccine Research Center at Beth Israel Deacones Medical Center, has a two-step experiment to produce a vaccine with SARS-CoV- Verified to protect rhesus monkey from 2.
In the first experiment, 9 unvaccinated rhesus monkeys were infected with SARS-CoV-2 to see if the rhesus monkeys infected with SARS-CoV-2 produce antibodies. As a result, rhesus monkeys showed moderate COVID-19 symptoms such as pneumonia. Rhesus monkeys recovered from COVID-19 within a few days, so the team examined the rhesus monkey's antibody levels and found that the recovered rhesus monkeys were expressing antibodies to SARS-CoV-2.
35 days after the SARS-CoV-2 inoculation, when the research team again vaccinated the rhesus monkeys with SARS-CoV-2, the rhesus monkeys did not show COVID-19 symptoms. A test for antibody levels also confirmed that there was a surge of antibodies again in the rhesus monkey.
"If the antibody didn't work well in this experiment, the effort to develop a vaccine would be pointless, which is a nightmare for 7 billion people," Barouch said. It should have been news like this. "
Based on the results that the rhesus antibody protected rhesus monkeys from SARS-CoV-2, the research team actually created 6 types of vaccines using the SARS-CoV-2 gene. Each vaccine was given to a total of 25 rhesus monkeys, 4-5 each. Then, 3 weeks after the vaccination, I was vaccinated with SARS-CoV-2.
As a result, some vaccines worked poorly, but some did. In particular, 8 out of 25 animals could not detect any trace of SARS-CoV-2 at all.
Barouch said about the results of the two experiments: "This is very positive news for vaccine development efforts. Further research is needed on whether vaccines and antibodies are effective in humans, but 93% of humans and DNA. Promising results from rhesus macaques that share this will broaden the optimistic view that it is never impossible to make an effective vaccine against COVID-19. "