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It is confirmed in monkey experiments that antibodies that protect the body from novel coronavirus are produced by vaccine


Science

It is confirmed in monkey experiments that antibodies that protect the body from novel coronavirus are produced by vaccine

Conducted by a research team at Harvard Medical School,Rhesus monkeyTo prototypeDNA vaccineAnd an experiment inoculating the new coronavirus (SARS-CoV-2) confirmed that the vaccine protects rhesus monkeys from SARS-CoV-2. It is reported that the expectation that this will lead to the development of a new type of coronavirus infectious disease (COVID-19) vaccine for humans is increasing.

DNA vaccine protection against SARS-CoV-2 in rhesus macaques | Science
https://science.sciencemag.org/content/early/2020/05/19/science.abc6284

Immunity to COVID-19 Appears Feasible | Harvard Magazine
https://harvardmagazine.com/2020/05/covid-19-immunity


Prototype Vaccines Protect Monkeys From Coronavirus | Boston.com
https://www.boston.com/news/coronavirus/2020/05/20/prototype-vaccines-protect-monkeys-from-coronavirus

Monkey trials at Harvard Medical School show promising vaccine results-CBS News
https://www.cbsnews.com/news/coronavirus-monkey-trials-harvard-medical-school-promising-vaccine-results/

Dan H. Barouch, a professor of medicine at the Harvard Medical School and director of the Virology and Vaccine Research Center at Beth Israel Deacones Medical Center, has a two-step experiment to produce a vaccine with SARS-CoV- Verified to protect rhesus monkey from 2.

In the first experiment, 9 unvaccinated rhesus monkeys were infected with SARS-CoV-2 to see if the rhesus monkeys infected with SARS-CoV-2 produce antibodies. As a result, rhesus monkeys showed moderate COVID-19 symptoms such as pneumonia. Rhesus monkeys recovered from COVID-19 within a few days, so the team examined the rhesus monkey's antibody levels and found that the recovered rhesus monkeys were expressing antibodies to SARS-CoV-2.

35 days after the SARS-CoV-2 inoculation, when the research team again vaccinated the rhesus monkeys with SARS-CoV-2, the rhesus monkeys did not show COVID-19 symptoms. A test for antibody levels also confirmed that there was a surge of antibodies again in the rhesus monkey.

"If the antibody didn't work well in this experiment, the effort to develop a vaccine would be pointless, which is a nightmare for 7 billion people," Barouch said. It should have been news like this. "

Based on the results that the rhesus antibody protected rhesus monkeys from SARS-CoV-2, the research team actually created 6 types of vaccines using the SARS-CoV-2 gene. Each vaccine was given to a total of 25 rhesus monkeys, 4-5 each. Then, 3 weeks after the vaccination, I was vaccinated with SARS-CoV-2.

As a result, some vaccines worked poorly, but some did. In particular, 8 out of 25 animals could not detect any trace of SARS-CoV-2 at all.

Barouch said about the results of the two experiments: "This is very positive news for vaccine development efforts. Further research is needed on whether vaccines and antibodies are effective in humans, but 93% of humans and DNA. Promising results from rhesus macaques that share this will broaden the optimistic view that it is never impossible to make an effective vaccine against COVID-19. "

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