It is pointed out that the experiment that produced the genetically edited baby failed and caused “ unintentional mutation ''


It is pointed out that the experiment that produced the genetically edited baby failed and caused “ unintentional mutation ''

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In 2018, Chinese researcher He Jiankui of Nankata University of Science and Technology will be able to freely exchange the DNA genome sequence.CRISPR-Cas9”And succeeded in creating twins resistant to HIV through gene editing.”AnnouncementDid. Mr. Ka thenMissingHowever, as a result of an expert review of a copy of an unpublished paper, it is reported that "the study is likely to have failed".

China gene-edited baby experiment 'may have created unintended mutations' | Science | The Guardian

Scientists slam Chinese gene-edited babies research after manuscript released-CNA

China's failed gene-edited baby experiment proves we're not ready for human embryo modification

After the research contents were announced in November 2018, in January 2019 the existence of twins of “ Ru '' and “ Nana '' that were genetically edited was confirmed, Mr. Ga It was reported that it was subject to the investigation. On the other hand, Mr. Ga has not appeared in public since attending an international conference in Hong Kong at the end of November 2018 and published his research results. "Isn't it restrained?"

Chinese scientists who confirmed the existence of genome-edited twins in China and conducted clinical experiments are subject to police investigation-GIGAZINE

Meanwhile, in science and technology magazinesMIT Technology ReviewIn early 2019, he got a copy of his unpublished paper from an anonymous source. Mr. Ka at least wrote his paperNatureWhenJAMAIt seems that it was posted to, but both academic journals have refused to be published as a result of examination.

Many criticisms were gathered in his research, but the papers and experimental data were not published, and details remained unknown. So the science writerAntonio RegaladoHe has published unpublished papers as a lawyer,In vitro fertilizationDoctors, embryologists, and gene editing specialists reviewed and examined the validity of the study. As a result, Mr. Kaga's research has revealed a number of issues, including deviations from ethics and scientific norms.

First, Mr. Ka widely claimed that "it was possible to confer HIV resistance to the baby by gene editing technology", but there was no data that actually succeeded in giving the baby HIV resistance . Some peopleCCR5It is known that people with this type of mutation are resistant to HIV. Mr. Ga claimed that the mutation of CCR5 was reproduced by gene editing to make the baby resistant to HIV, but according to the reviewing experts, Mr. Ka said his attempt was unsuccessful .

He's research team certainly did gene editing targeting CCR5, but it wasn't able to completely reproduce the known mutations, and “ mutations that may not lead to the acquisition of HIV resistance "The expert pointed out."University of California, BerkeleyStudy gene editing atFyodor UrnovThe professor accused "the claim that they recreated the CCR5 mutation is an explicit misrepresentation of the actual data and can be said to be 'intentional deception'."

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Also, CRISPR is not a perfect tool, and when trying to edit one gene, there are cases where other genes are changed unintentionally. However, it became clear that his research team only examined one of the early embryos to verify the results of the gene editing, and did not perform comprehensive verification.

In addition to these doubts about the experimental results, it is pointed out that Mr. Kaga's experimental methods and papers may have various deficiencies. For example, the author list of a paper does not include the name of the doctor or obstetrician who was responsible for infertility treatment. This point hurts the reliability of the paper, and it is possible that doctors were allowed to cooperate in the experiment without being informed of the fact that they were "involved in research on gene editing technology". There seems to be.

In addition, he said, “The baby's father was HIV-infected and had given up having a child because of his illness, but this experiment gave him a child,” There are still doubts about this. Because HIV is not inherited and develops only by infection with the HIV virus, it is possible to safely give children by simply removing the HIV virus from the sperm by washing the sperm. Reproductive endocrinologist Jeanne O'Brien pointed out that "the inability of parents to receive infertility treatment due to social circumstances in China may have motivated them to participate in this experiment." did.

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