It turns out that parasites manipulate rat anxiety and disgust


It turns out that parasites manipulate rat anxiety and disgust

by Lodewijk Hertog

Parasitic protozoaToxoplasmaPrevious studies have shown that parasites in rodents cause the host to lose its "fear of predators". However, according to the latest study published on January 14, 2020, rodents infected with Toxoplasma do not lose “ fear of predators '' but rather “ general anxiety '' or “ It has been shown that you lose your “aversion to threats”.

Neuroinflammation-Associated Aspecific Manipulation of Mouse Predator Fear by Toxoplasma gondii: Cell Reports

Cat parasite reduces general anxiety in infected mice, not just fear of feline predators | EurekAlert! Science News

Toxoplasma is a single-cell parasite that parasitizes constant-temperature animals, including humans, to produce protozoal infections.ToxoplasmosisCause. More than 40 million people in the United States may be infected with Toxoplasma, because Toxoplasma may stay in the host for long periods of time. In addition, toxoplasmosis may cause fetal death if it is first infected during pregnancy. In addition, toxoplasmosis poses a major threat to people with compromised immune systems, such as those infected with HIV. It seems that about 30% of the world's population may be infected with toxoplasma, and toxoplasmosis is a risk factor for psychiatric disorders such as schizophrenia, parkinsonism, bipolar disorder, traffic accidents and attempted suicide There is also.

Ivan Rodríguez and his colleagues at the University of Geneva, who are studying Toxoplasma, have reported their latest research on Toxoplasma in journals.Cell ReportsAnnounced.

"For the past two decades, Toxoplasma has been used as a demonstration of the parasite's specificity. Infection with Toxoplasma has altered the behavior of rats. It has been thought to be about "fear" of cats, but it is not the only thing: (infection with Toxoplasma) can cause major changes in the mouse brain itself, affecting various behaviors and nervous functions. It has been suggested. "

by Yale Rosen

Previous studies have shown that rats infected with Toxoplasma become less fearful of their predator cats. It has also been shown that infected mice no longer have an aversion to cat odor. Then, after a mouse infected with Toxoplasma is eaten by the cat, Toxoplasma spreads to various hosts through the feces of the cat.

“ Our first idea was to investigate the molecular mechanisms behind behavioral changes (resulting from Toxoplasma infection), '' said Dominique Soldati Fabre of the University of Geneva, who worked on the latest Toxoplasma research. However, we have decided to reevaluate the doctrine of the changes that occur in rats infected with Toxoplasma, given the multiple contradictory results that have been reported so far. "

by Kong Jun

The latest study by Rodriguez and Fabre and colleagues has shown that mice infected with Toxoplasma do not selectively reduce only "fear of predator cats." In the investigation, experiments were performed using a maze between mice infected with Toxoplasma 5 to 10 weeks after passage and non-infected mice. Mice not infected with Toxoplasma appear to evade / defend against potential threats (experimenter's hand) and respond to anxiety. Mice infected with Toxoplasma, on the other hand, seemed to touch the hands of the experimenter immediately, suggesting that they were insensitive to potential threats.

“ To summarize, these findings show that chronic toxoplasma infection reduces anxiety and risk aversion, and increases curiosity and exploratory behavior, '' said co-author Madrina Boylat. Suggests. "

Other experiments have shown that infection with toxoplasma reduces the predator's fear of various animals. Experiments show that mice infected with Toxoplasma are clearly attracted to bobcat urine, but uninfected mice respond in the opposite way. Also, mice infected with Toxoplasma seem to spend more time investigating the odor of guinea pigs and foxes than non-infected mice. In addition, it has been revealed that mice infected with Toxoplasma took bold actions such as walking on rats.

Pierre Medi Hammoudi, who participated in the experiment, said about the experimental results that “ Toxoplasma alters the behavior of the host is that '(toxoplasma) targets only neural circuits that respond to predators' This contrasts with the idea of ​​"", and emphasized that the results were different from the results of previous research.

by Nina Mercado

In addition, the group used lightsheet microscopy to accurately map the distribution, size, and cyst tissue throughout the brain at an unprecedented level of high-resolution. The subjects of the survey were mice infected with Toxoplasma for 10 to 12 weeks. As a result of the investigation, it was apparent that the toxoplasma in the cerebral cortex of the mouse brain, which is particularly involved in processing visual field information, was filled with high density. However, the number and distribution of cysts vary greatly from mouse to mouse, suggesting that the infection and dissemination processes vary from individual to individual.

Additional analysis has also shown that the severity of behavioral changes induced by infection with Toxoplasma is related to the amount of cysts and neuroinflammation. "In summary, Toxoplasma does not 'directly interfere with specific neuronal populations' but 'changes the behavior mediated by neuronal inflammation', and this response is not a simple on-off system," said Rodriguez. In the future, when studying the effects of Toxoplasma on the host, chronic infection levels must always be considered. "

The research team will further study how neuroinflammation alters behavioral characteristics such as anxiety, sociability, and curiosity.

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