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Possibility of "because baldness makes new coronavirus infection severe"


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Possibility of "because baldness makes new coronavirus infection severe"

by David Fulmer

Previous studies have found that men have a higher risk of severe coronavirus infection (COVID-19) than females, but among such men, bald people have a particularly high risk of seriousness. The results have been announced.

A preliminary observation: Male pattern hair loss among hospitalized COVID‐19 patients in Spain – A potential clue to the role of androgens in COVID‐19 severity-Goren-2020-Journal of Cosmetic Dermatology-Wiley Online Library
https://onlinelibrary.wiley.com/doi/full/10.1111/jocd.13443

Androgenetic Alopecia Present in the Majority of Hospitalized COVID-19 Patients – the “Gabrin sign”-Journal of the American Academy of Dermatology
https://www.jaad.org/article/S0190-9622(20)30948-8/fulltext

Bald men at higher risk of severe case of Covid-19, research finds
https://www.telegraph.co.uk/global-health/science-and-disease/bald-men-higher-risk-severe-case-covid-19-research-finds/

Coronavirus and sex hormones — baldness may be a risk factor and anti-androgens a treatment
https://theconversation.com/coronavirus-and-sex-hormones-baldness-may-be-a-risk-factor-and-anti-androgens-a-treatment-140340

Whether or not COVID-19 becomes severe depends onGender, age, chronic diseaseSmoking historyThe mortality rate for men is calculated to be about twice that for women.

Regarding the risk of COVID-19 becoming severe, several studies have been published that "thinning hair has a particularly high risk of becoming severe". 79% of men with COVID-19 infections in three hospitals in Madrid, Spain, had thin hair, according to a paper jointly published by American and Spanish researchers. In the age group of the targeted patients, the proportion of men who suffer from thinning hair is about 31 to 53%, so the proportion of patients with severe COVID-19 suffering from thinning hair is about twice the normal rate. Although women have the biological characteristic of being less prone to thinning hair, this study also confirmed that thinning hair and COVID-19 aggravation are also associated with women.

What is associated with thinning hair is the risk of COVID-19 becoming more severe:Male pattern baldnessAffectAndrogenIt is thought to be due to the male hormone. A proteolytic enzyme that plays an important role when a new coronavirus enters cellsType II transmembrane serine protease(TMPRSS2)” is activated when it binds to the androgen receptor, so it is considered that the more the male hormone, the androgen receptor, TMPRSS2, the more likely COVID-19 becomes severe. Of the University of California and Yale, which investigated the relationship between androgens and COVID-19the studyAlso concluded that the higher the androgen concentration in the blood, the higher the probability of COVID-19 infection and severity of COVID-19.

Inhibits androgen receptor binding following a series of studiesAntiandrogenIs being investigated for its effectiveness. Antiandrogens are not newly developed drugs for the treatment of COVID-19, but are safe as drugs for treating prostate cancer, benign prostatic hyperplasia, and male pattern baldness. There is an advantage that the experiment can proceed without it.

In Italy for men with prostate cancerUniversity of PaduaAccording to a study of the administration of anti-androgensAndrogen blockade therapyIt was found that men who received COVID-19 had a one-quarter chance of being infected with COVID-19 compared to men who did not receive androgen blockade therapy. It has been suggested that even if the anti-androgen drug is administered immediately after exposure to the new coronavirus, the probability of infection will be reduced.

It should be noted that anti-androgens swell the breasts of men like breasts of womenGynecomastiaDue to side effects such as decreased sexual desire and libido, medical monitoring is essential for administration.

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