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Researchers report that pertussis is evolving into a “ super bug '' where antibiotics do not work


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Researchers report that pertussis is evolving into a “ super bug '' where antibiotics do not work

By Rawpixel

A respiratory infection characterized by a long-lasting medical condition that is said to take 100 days to completely cureWhooping cough"But,AntibioticsResistant toDrug resistant bacteria(Super bug)That Australia is becomingNew South Wales UniversityResearch team revealed.

Surfaceome analysis of Australian epidemic Bordetella pertussis reveals potential vaccine antigens-ScienceDirect
https://www.sciencedirect.com/science/article/pii/S0264410X19314422

Whooping cough evolving into a superbug | UNSW Newsroom
https://newsroom.unsw.edu.au/news/health/whooping-cough-evolving-superbug

Evidence Shows Whooping Cough Is Evolving Into a 'Superbug', Scientists Warn
https://www.sciencealert.com/whooping-cough-may-evolve-into-a-superbug-if-we-don-t-do-something-scientists-warn

Whooping cough is a respiratory infection that spreads through droplet infection, and when it starts in full swing, a convulsive cough appears repeatedly. The number of pertussis patients worldwide is about 16 million annually, of which 70% are younger than 5 years and 38% are less than 6 months old. Under 1 year mortality is about 1% to 2%, killing tens of thousands of people every year.

Such a whooping cough,Pertussis vaccine"Can be prevented by inoculation. However, a research team at the University of New South Wales has shown that whooping cough is becoming resistant to a vaccine, a cell-free vaccine.

The research team analyzed the protein that wraps Bordetella pertussis (pertussis) on a cell-by-cell basis and found that moreNutrition binding proteinWhenMembrane transporterIt turned out to be producing. This change indicates "metabolic adaptation" of B. pertussis,Immune systemIt may be evolving to deprive the host of nutrients more efficiently while avoiding the response of the host. "In simple terms, B. pertussis is evolving into a superbug, with better 'hiding' and 'securing food'," said lead author Dr. Lawrence Lou.

By maxxyustas

A superbug is "a bacterium that does not work with antibiotics." HumanityPathogenic E. coliAntibiotics have been developed to exclude harmful bacteria like the body from the body, but cells have evolved so that antibiotics do not work. The struggle for survival between humans and bacteria is endless.

Dr. Lou explains that the evolved B. pertussis is good at hiding, so it can be transmitted to vaccinated people. The evolved B. pertussis does not provoke an immune response, so it is said to be "free of symptoms even if infected". In this case, the affected person is not aware that he has “pertussis”, so the infection is easier to spread than before.

By seventyfourimages

Prof. Ruiting Lan, who led the research team, stated that "a new vaccine effective against B. pertussis should be developed" and reiterated that "vaccine vaccination with conventional vaccines should be continued." "The number of cases of whooping cough has been increasing over the past decade, but it has remained low compared to before the pertussis vaccine was introduced. To protect newborns that are not resistant to pathogens," said Lan. High vaccination rates need to be maintained, and vaccination is especially important for those who come into contact with children and pregnant women. "

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